Aim: This study was conducted to determine the effects of CoQ10 supplementation on some liver enzymes in diabetes status.Materials and Methods: In the study, 38 healthy male Wistar Albino rats were used.The rats were divided into five groups.The animals in group 1, group 2 and group 3 were received standard diet, standard diet plus IP 0,3 ml corn oil and standard diet plus IP 10 mg/kg CoQ10 for four weeks, respectively.In group 4, diabetes was performed via SC igora vibrance 6-16 injections of Streptozotocin (STZ) at dose of 40 mg/kg in 0.
1 M citrate buffer (pH 4.5) single daily dose for two days.In group 5, diabetes was made via SC injections of STZ at a dose of 40 mg/kg in 0.1 M citrate buffer (pH 4.5) single daily dose for two days and then received IP 10 mg/kg CoQ10 for four weeks.
At the end of the fourth week, blood ole miss stripe out samples were taken from all animals.In plasma samples, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (GGT) levels were determined.Results: In diabetic rats, RBC, hemoglobin and hematocrit values were determined to be lower (p Conclusions: In conclusion, it is thought that CoQ10 supplementation may be beneficial on liver damage resulting from hazardous effects of diabetes.